SA-Eluting Bone Regeneration Scaffolds

Biodegradable scaffolds that release salicylic acid as new bone grows in — undergraduate research at Rutgers.

Microfluidics work from the scaffold project

Overview

This was my undergraduate research at Rutgers, and the first paper I had my name on. The work was on biodegradable bone regeneration scaffolds that release salicylic acid locally as they break down — the idea being that a scaffold can do two jobs at once, holding structure while new bone grows into it and delivering an anti-inflammatory to the site over time instead of all at once.

The scaffolds needed interconnected porosity so cells and nutrients could actually get through them, which is where most of the fabrication difficulty lives. I was one of ten authors on the resulting paper; this was a lab effort and I was an undergrad in it, not the person driving it.

Publication

W. Yu, J. Bajorek, S. Jayade, A. Miele, J. Mirza, S. Rogado, A. Sundararajan, J. Faig, L. Ferrage, K. Uhrich. "Salicylic acid (SA)‑eluting bone regeneration scaffolds with interconnected porosity and local and sustained SA release." Journal of Biomedical Materials Research Part A, 2017.

The paper has the actual methods and results; I'd rather point you at it than paraphrase it from memory a decade later.